2Department of General Surgery, Sivas Cumhuriyet University Faculty of Medicine, Sivas-Türkiye
3Department of Medical Pathology, Sivas Cumhuriyet University Faculty of Medicine, Sivas-Türkiye DOI : 10.5505/tjo.2025.4687 OBJECTIVE
This study aimed to investigate the relationship and prognostic value of the Gustave Roussy Immune Score (GRIm Score), quantitative 18F-FDG PET/CT parameters, and histopathological features in operable pancreatic ductal adenocarcinoma (PDAC) patients.
METHODS
We retrospectively analysed 18F-FDG PET/CT data, routine pre-operative blood tests (for GRIm Score),
and post-surgical pathology (LVI, PNI, etc.) from 41 operable PDAC patients (2016-2024). The GRIm
Score (0-3) was determined using LDH, Albumin, and NLR. Patients were categorized into low (0-1)
and high (2-3) GRIm groups for statistical evaluation.
RESULTS
No significant correlation was found between the GRIm score and PET/CT or pathology features. Mean
overall survival was 12.97 months. Patients with high GRIm scores showed significantly shorter survival
(6.2 months vs. 16.7 months, p<0.001). Multivariate survival analysis confirmed that both the GRIm
score (HR=10.258, p<0.001) and the presence of LVI (HR=14.899, p=0.019) were independent prognostic
factors. Other parameters did not show a significant association with survival.
CONCLUSION
The GRIm score, easily and cost-effectively calculated from routine blood tests, holds significant and
independent prognostic value in operable PDAC patients. Its independence from conventional tumor
features suggests promising potential for assessing prognosis.