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Anadolu Sağlık Merkezi, Tibbi Onkoloji, Kocaeli Short-term therapy of tamoxifen-induced severe hypertriglyceridemia and acute pancreatitis in a patient with breast cancer is described in this article. Interestingly, no pre-existing history of dyslipidemia was noted in comparison to the relevant literature review. Tamoxifen is the most widely used anti-estrogen in adjuvant endocrine treatment of primary breast cancer. However, due to its estrogen-like activity in lipid metabolism, a small increase in serum triglycerides is also commonly found in long-term users. This finding is usually insignificant and without clinical manifestations. Keywords : Pancreatitis; tamoxifen; triglycerides