TURKISH JOURNAL OF ONCOLOGY 1998 , Vol 13 , Num 4
IMMUNOHISTOCHEMICAL EXPRESSION OF P53 PROTEIN AND PCNA IN GASTRIC MUCINOUS ADENOCARCINOMAS
GÜLEN DOĞUSAY, SÜHA GÖKSEL, HAYDAR DURAK, IŞIL PAKİŞ, GÖKHAN ERSOY, SELDA GÖKÇENER
Cerrahpaşa Tıp Fakültesi, Patoloji Anabilim Dalı, İstanbul The aim of this study is to review the histopathological features and to examine the immunohistochemical expression of tumor supressor gene; p53 protein and proliferating cell nuclear antigen (PCNA) in gastric mucinous adenocarsinomas. Among 24 cases, 46% have high proliferative activity by PCNA labeling index. When PCNA labeling index and p53 expression have been correlated with clinicopathologic characteristics, no significant association has been found statistically, except a significant association between age and PCNA activity. Keywords :