2Department of Pathology, Kocaeli University Faculty of Medicine Hospital, Kocaeli-Turkey DOI : 10.5505/tjo.2021.3380 OBJECTIVE
It was aimed to reevaluate uterine sarcoma cases diagnosed in our institution within the last 20 years according to current information and to provide intra-departmental standardization in the differential diagnosis and reporting.
METHODS
Totally 84 uterine sarcoma cases were re-examined. Recurrence, metastasis, and prognostic data were
collected from the patient files. Immunohistochemistry panel consisting of CD10, h-caldesmon, and
cyclin D1 was applied to the representative tumor tissues. The relationships between the parameters
studied were evaluated statistically.
RESULTS
Statistically significant differences were found between different histopathological types of uterine sarcomas
(US) in terms of age distribution, tumor diameter, mitotic index, necrosis, depth of myometrial
invasion, cervical, adnexial and/or omental involvement, lymphovascular invasion, lymph node metastasis,
recurrence, and distant metastasis. Statistically significant correlation was determined between the
prognosis of the patients and mitotic activity of their tumors and the presence of distant metastasis. The
immunohistochemistry panel was found to have significant contribution to the histomorphological examination
in the differential diagnosis.
CONCLUSION
Routine use of CD10, h-caldesmon, and cyclin D1 in the histopathological evaluation of US and establishing
an updated standard checklist was thought to be beneficial for the differential diagnosis and
reporting prognostic parameters.