A Case of Epithelial-Myoepithelial Carcinoma in the Nasal Cavity Treated with Definitive Chemoradiotherapy
Beyza Şirin ÖZDEMİR1,Melek Gamze AKSU1,Alper Tunga DERİN2,Havva Serap TORU3,Kamil KARAALİ4,Mine GENÇ1
1Department of Radiation Oncology, Akdeniz University Faculty of Medicine, Antalya-Turkey
2Department of Otorhinolaryngology, Akdeniz University Faculty of Medicine, Antalya-Turkey
3Department of Pathology, Akdeniz University Faculty of Medicine, Antalya-Turkey
4Department of Radiology, Akdeniz University Faculty of Medicine, Antalya-Turkey
DOI : 10.5505/tjo.2019.1818 Epithelial-myoepithelial carcinoma (EMC) is an uncommon neoplasm that is predominantly seen in major salivary glands. Although it is considered as low grade, the high recurrence rate is quite common. EMC of the nasal cavity is extremely rare. A case of EMC detected in the nasal cavity is reported. A 44-year-old woman presented with a 1-year history of nasal congestion and bleeding. Magnetic resonance imaging (MRI) revealed a 4×4 cm necrotic expansile lesion involving the bilateral nasal cavity, extending to the nasopharynx, oral cavity, maxillary sinus, and ethmoid cells. The patient was found to be inoperable since complete surgical resection was not possible, and excisional biopsy was performed. Histopathological and immunohistochemical analyses led to a diagnosis of EMC. Definitive radiotherapy (RT) with concomitant cisplatin was applied. After 4 years, the patient is asymptomatic, and MRI showed a stable status with no progression. EMC is rarely seen in the nasal cavity. If possible, the first treatment modality should be surgery. The role of RT is controversial. To the best of our knowledge, this is the only case treated with definitive chemoradiotherapy for EMC in the nasal cavity. Keywords : Chemotherapy; epithelial?myoepithelial carcinoma; nasal cavity; radiotherapy